STANOZOLOL 10mg – TABLETS

Stanozolol 10mg

Molecular Formula:

C21H32N2O

Molecular Weight:

328.5 g/mol

Structure:

DESCRIPTION

Stanozolol is an oral androgen, a derivative of Dihydrotestosterone (DHT). Stanozo- lol was originally developed to treat hereditary angioedema. As with most Androgens Stanozolol will help to create a state of anabolism and contribute to a significant increase in muscle tissue. Structurally, stanozolol is not capable of converting into estrogen therefore will not contribute to water retention which may be the case with other androgens. Also unlike most anabolic steroids, is not esterified. The drug has a large oral bioavailability, due to a C17 α-alkylation which allows the hormone to survive first pass liver metabolism when ingested.

CLINICAL PHARMACOLOGY

Anabolic steroids such as Stanozolol are synthetic derivatives of testosterone. Stanozolol has been found to increase low-density lipoproteins and decrease high-density lipoproteins. These changes are not associated with any increase in total cholesterol or triglyceride levels and revert to normal on discontinuation of treatment.

Hereditary angioedema (HAE) is an autosomal dominant disorder caused by a defi- cient or nonfunctional C1 esterase inhibitor (C1 INH) and clinically characterized by episodes of swelling of the face, extremities, genitalia, bowel wall, and upper respi- ratory tract.

In small clinical studies, Stanozolol was effective in controlling the frequency and severity of attacks of angioedema and in increasing serum levels of C1 INH and C4. Stanozolol is not effective in stopping HAE attacks while they are under way. The effect of stanozolol on increasing serum levels of C1 INH and C4 may be related to an increase in protein anabolism.

INDICATION AND USES

Hereditary Angioedema: Stanozolol is indicated prophylactically to decrease the fre- quency and severity of attacks of angioedema.

CONTRAINDICATIONS

The use of Stanozolol is contraindicated in the following:

Male patients with carcinoma of the breast or with known or suspected carcinoma of the prostate.

Carcinoma of the breast in females with hypercalcemia; androgenic anabolic ste- roids, may stimulate osteolytic resorption of bone.

Nephrosis or the nephrotic phase of nephritis.

Stanozolol can cause fetal harm when administered to a pregnant woman. Stanoz- olol is contraindicated in women who are or may become pregnant while taking this drug; the patient should be apprised of the potential hazard to the fetus.

PRECAUTIONS

General: Anabolic steroids may cause suppression of clotting factors II, V, VII and X and an increase in prothrombin time.

Women should be observed for signs of virilization (deepening of the voice, hirsut- ism, acne, and clitoromegaly). To prevent irreversible change, drug therapy must be discontinued, or the dosage significantly reduced when mild virilism is first detected.

Such virilization is usual following androgenic anabolic steroid use of high doses. Some virilizing changes women are irreversible even after prompt discontinuance of therapy and are not prevented by concomitant use of estrogens. Menstrual irregu- larities may also occur.

Oral hypoglycemic dosage may need adjustment in diabetic patients who receive anabolic steroids.

DRUG INTERACTIONS

Stanozolol may increase sensitivity to anticoagulants; therefore, dosage of antico- agulants may have to be decreased in order to maintain the prothrombin time at the desired therapeutic level.

ADVERSE REACTIONS

Hepatic: Cholestatic jaundice with rarely, hepatic necrosis and death. Hepatocellular neoplasms and peliosis hepatis have been reported in association with long term androgenic anabolic steroid. Reversible changes in liver function tests also occur including increased bromsulphalein (BSP) retention and increases in serum bilirubin, glutamic oxaloacetic transaminase (SGOT), and alkaline phosphatase.

Genitourinary System (Prepubertal men): Phallic enlargement and increased fre- quency of erections.

Genitourinary System (Post pubertal men): Inhibition of testicular functions, testicu- lar atrophy, and oligospermia, impotence, chronic priapism, epididymitis and bladder irritability.

Genitourinary System (Women): Clitoral enlargement, menstrual irregularities. In both sexes: increased or decreased libido.

CNS: Habituation, excitation, insomnia, and depression. Gastrointestinal: Nausea, vomiting, diarrhea.

Hematologic: Bleeding in patients on concomitant anticoagulant therapy. Breast: Gynecomastia.

Larynx: Deepening of the voice in women.

Hair: Hirsutism and male pattern baldness in women. Skin: Acne (especially in women and prepubertal boys.) Skeletal: Premature closure of epiphyses in children.

Fluid and Electrolytes: Edema, retention of serum electrolytes (Sodium chloride, po- tassium, phosphate, and calcium).

DOSAGE AND ADMINISTRATION

The use of anabolic steroids may be associated with serious adverse reactions. Many of which are dose related; therefore patients should be placed on the lowest possible effective dose.

Hereditary Angioedema. The dosage requirements for continuous treatment of he- reditary angioedema with stanozolol should be individualized on the basis of clini- cal response of the patient. It is recommended the patient be started on 2 mg three times a day. After a favorable initial response is obtained in terms of prevention of episodes of edematous attacks, the proper continuing dosage should be determined by decreasing the dosage at intervals of one to three months to a maintenance dosage of 2 mg alternate day schedule. During the dose-adjusting phase close mon- itoring of the patient’s has a history of airway involvement.

The prophylactic dose of stanozolol to be used prior to dental extraction or other traumatic or stressful situations has not been established and may be substantially larger.

PACKAGING

10 mg/tablets, 100 tablets per box

STORAGE

Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.